1. Agarwal, A. K., Raja, A. & Brown, B. D. Chronic Obstructive Pulmonary Disease. in StatPearls (StatPearls Publishing, Treasure Island (FL), 2022).
2. GLOBAL STRATEGY FOR PREVENTION, DIAGNOSIS AND MANAGEMENT OF COPD: 2025 Report.
3. Boers, E. et al. Global Burden of Chronic Obstructive Pulmonary Disease Through 2050. JAMA Netw Open 6, e2346598 (2023).
4. Miravitlles, M. & Ribera, A. Understanding the impact of symptoms on the burden of COPD. Respir Res 18, 67 (2017).
5. Marciniuk, D. D. et al. Managing dyspnea in patients with advanced chronic obstructive pulmonary disease: A Canadian Thoracic Society clinical practice guideline. Can Respir J 18, 69–78 (2011).
6. Negewo, N. A., McDonald, V. M. & Gibson, P. G. Comorbidity in chronic obstructive pulmonary disease. Respir Investig 53, 249–258 (2015).
7. NIH. COPD - Sympotms (https://www.nhlbi.nih.gov/health/copd/symptoms - ultimo accesso ottobre 2025).
8 .Hurst, J. R. et al. Understanding the impact of chronic obstructive pulmonary disease exacerbations on patient health and quality of life. European Journal of Internal Medicine 73, 1–6 (2020).